• AI Risk Score on Screening Mammograms Preceding Breast Cancer Diagnosis 

      Larsen, Marthe; Olstad, Camilla Flåt; Koch, Henrik Wethe; Martiniussen, Marit Almenning; Hoff, Solveig Kristin Roth; Lund-Hanssen, Håkon; Solli, Helene; Mikalsen, Karl Øyvind; Auensen, Steinar; Nygård, Jan Franz; Lång, Kristina; Chen, Yan; Hofvind, Solveig Sand-Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-17)
      More than 38% of both screen-detected and interval cancers were assigned the highest artificial intelligence risk score on screening mammograms that preceded breast cancer diagnosis.<p> <p>Background - Few studies have evaluated the role of artificial intelligence (AI) in prior screening mammography.<p> <p>Purpose - To examine AI risk scores assigned to screening mammography in women who were ...
    • Artificial Intelligence Evaluation of 122969 Mammography Examinations from a Population-based Screening Program 

      Larsen, Marthe; Aglen, Camilla Flåt; Lee, Christoph I.; Hoff, Solveig Roth; Lund-Hanssen, Håkon; Lång, Kristina; Nygård, Jan Franz; Ursin, Giske; Hofvind, Solveig Sand-Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-29)
      Background - Artificial intelligence (AI) has shown promising results for cancer detection with mammographic screening. However, evidence related to the use of AI in real screening settings remain sparse.<p> <p>Purpose - To compare the performance of a commercially available AI system with routine, independent double reading with consensus as performed in a population-based screening program. ...
    • Artificial intelligence in BreastScreen Norway: a retrospective analysis of a cancer-enriched sample including 1254 breast cancer cases 

      Koch, Henrik Wethe; Larsen, Marthe; Bartsch, Hauke; Kurz, Kathinka Dæhli; Hofvind, Solveig Sand-Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-14)
      Objectives To compare results of selected performance measures in mammographic screening for an artifcial intelligence (AI) system versus independent double reading by radiologists.<p> <p>Methods In this retrospective study, we analyzed data from 949 screen-detected breast cancers, 305 interval cancers, and 13,646 negative examinations performed in BreastScreen Norway during the period from 2010 ...
    • Breast cancer missed at screening; hindsight or mistakes? 

      Hovda, Tone; Larsen, Marthe; Romundstad, Linda; Sahlberg, Guro Kristine Kleivi; Hofvind, Solveig Sand-Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-03)
      Purpose - To investigate radiologists’ interpretation scores of screening mammograms prior to diagnosis of screen-detected and interval breast cancers retrospectively classified as missed or true negative.<p> <p>Methods - We included data on radiologists’ interpretation scores at screening prior to diagnosis for 1223 screen-detected and 1007 interval cancer cases classified as missed or true ...
    • Clinical guided computer tomography decisions are advocated in potentially severely injured trauma patients: a one-year audit in a level 1 trauma centre with long pre-hospital times 

      Bågenholm, Anna; Dehli, Trond; Hermansen, Stig Eggen; Bartnes, Kristian; Larsen, Marthe; Ingebrigtsen, Tor (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-10)
      <i>Background</i> - The International Commission on Radiological Protection’s (ICRP) justification principles state that an examination is justified if the potential benefit outweighs the risk for radiation harm. Computer tomography (CT) contributes 50% of the radiation dose from medical imaging, and in trauma patients, the use of standardized whole body CT (SWBCT) increases. Guidelines are lacking, ...
    • Cumulative risk of a false-positive screening result: A retrospective cohort study using empirical data from 10 biennial screening rounds in BreastScreen Norway 

      Tsuruda, Kaitlyn; Larsen, Marthe; Roman, Marta; Hofvind, Solveig (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-21)
      <p><b>Background</b> False-positive screening results are an inevitable and commonly recognized disadvantage of mammographic screening. This study estimated the cumulative probability of experiencing a first false-positive screening result in women attending 10 biennial screening rounds in BreastScreen Norway, which targets women aged 50 to 69 years. <p><b>Methods</b> This retrospective ...
    • Early performance measures following regular versus irregular screening attendance in the population-based screening program for breast cancer in Norway 

      Thy, Jonas Evensen; Larsen, Marthe; Vigeland, Einar; Koch, Henrik Wethe; Hovda, Tone; Hofvind, Solveig Sand-Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-11)
      Irregular attendance in breast cancer screening has been associated with higher breast cancer mortality compared to regular attendance. Early performance measures of a screening program following regular versus irregular screening attendance have been less studied. We aimed to investigate early performance measures following regular versus irregular screening attendance. Methods We used information ...
    • Early screening outcomes among non-immigrants and immigrants targeted by BreastScreen Norway, 2010–2019 

      Thy, Jonas Evensen; Bhargava, Sameer; Larsen, Marthe; Akslen, Lars Andreas; Hofvind, Solveig Sand-Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-31)
      Aims: This study aimed to analyse results on early screening outcomes, including recall and cancer rates, and histopathological tumour characteristics among non-immigrants and immigrants invited to BreastScreen Norway. Methods: We included information about 2, 763,230 invitations and 2,087,222 screening examinations from 805,543 women aged 50–69 years who were invited to BreastScreen Norway between ...
    • Factors associated with treatment in primary versus specialist care: A population-based study of people with type 2 and type 1 diabetes 

      Slåtsve, Kristina Barbara; Claudi, Tor; Lappegård, Knut Tore; Jenum, Anne Karen; Larsen, Marthe; Nøkleby, Kjersti; Cooper, John; Sandberg, Sverre; Berg, Tore Julsrud (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-08)
      <p>Aims: The objectives of this study are to identify the proportion and characteristics of people with type 1 and 2 diabetes treated in primary, specialist and shared care and to identify the proportion of persons with type 2 diabetes reaching HbA<sub>1c</sub> treatment targets and the clinical risk factors and general practitioner and practice characteristics associated with treatment in specialist ...
    • Group-based multimodal physical therapy in women with chronic pelvic pain: A randomized controlled trial 

      Nygaard, Ane Sigrid; Rydningen, Mona Birgitte; Stedenfeldt, Mona; Wojniusz, Slawomir; Larsen, Marthe; Lindsetmo, Rolv-Ole; Haugstad, Gro Killi; Øian, Pål (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-09)
      <p><i>Introduction - </i>Chronic pelvic pain in women is a complex condition, and physical therapy is recommended as part of a broader treatment approach. The objective of this study was to compare structured group‐based multimodal physical therapy in a hospital setting (intervention group) with primary‐care physical therapy (comparator group) for women with chronic pelvic pain. <p><i>Material and ...
    • Impact of the COVID-19 pandemic on breast cancer incidence and tumor stage in the Netherlands and Norway: A population-based study 

      Eijkelboom, Anouk H.; de Munck, Linda; Larsen, Marthe; Bijlsma, Maarten J.; Tjan-Heijnen, Vivianne C.G.; van Gils, Carla H.; Broeders, Mireille J.M.; Nygård, Jan Franz; Lobbes, Marc B.I.; Helsper, Charles W.; Pijnappel, Ruud M.; Strobbe, Luc J.A.; Wesseling, Jelle; Hofvind, Solveig Sand-Hanssen; Siesling, Sabine (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-27)
      Background - Comparing the impact of the COVID-19 pandemic on the incidence of newly diagnosed breast tumors and their tumor stage between the Netherlands and Norway will help us understand the effect of differences in governmental and social reactions towards the pandemic.<p< <p>Methods - Women newly diagnosed with breast cancer in 2017–2021 were selected from the Netherlands Cancer Registry and ...
    • Mammographic density and interval cancers in mammographic screening: Moving towards more personalized screening 

      Larsen, Marthe; Lynge, Elsebeth; Lee, Christoph I.; Lång, Kristina; Hofvind, Solveig Sand-Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-21)
      Purpose: The European Society on Breast Imaging has recommended supplemental magnetic resonance imaging (MRI) every two to four years for women with mammographically dense breasts. This may not be feasible in many screening programs. Also, the European Commission Initiative on Breast Cancer suggests not implementing screening with MRI. By analyzing interval cancers and time from screening to ...
    • Norwegian radiologists’ expectations of artificial intelligence in mammographic screening – A cross-sectional survey 

      Martiniussen, Marit Almenning; Larsen, Marthe; Larsen, Anne Sofie Frøyshov; Hovda, Tone; Koch, Henrik Wethe; Bjørnerud, Atle; Hofvind, Solveig Sand-Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-23)
      Purpose: To explore Norwegian breast radiologists’ expectations of adding artificial intelligence (AI) in the interpretation procedure of screening mammograms.<p> <p>Methods: All breast radiologists involved in interpretation of screening mammograms in BreastScreen Norway during 2021 and 2022 (n = 98) were invited to take part in this anonymous cross-sectional survey about use of AI in mammographic ...
    • Optimizing the Pairs of Radiologists That Double Read Screening Mammograms 

      Gommers, Jessie J.J.; Abbey, Craig K.; Strand, Fredrik; Taylor-Phillips, Sian; Jenkinson, David J.; Larsen, Marthe; Hofvind, Solveig Sand-Hanssen; Sechopoulos, Ioannis; Broeders, Mireille J.M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-24)
      Performance characteristics of mammography readers influenced the performance of pairs, but specific pairing strategies did not result in significantly different overall performance compared with that resulting from random pairing strategies.<p> <p>Background - Despite variation in performance characteristics among radiologists, the pairing of radiologists for the double reading of screening ...
    • Participation and cancer detection after reminders versus ordinary invitations in BreastScreen Norway 

      Thy, Jonas Evensen; Vigeland, Einar; Larsen, Marthe; Hofvind, Solveig Sand-Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-03)
      Objectives - To compare attendance, recall and cancer detection as well as histopathological tumor characteristics among women attending BreastScreen Norway after a reminder versus an ordinary invitation.<p> <p>Setting - This study was conducted on data from a population-based screening program inviting women aged 50–69 to biennial two-view mammography.<p> <p>Methods - We used de-identified ...
    • Personalized Breast Cancer Screening: A Risk Prediction Model Based on Women Attending BreastScreen Norway 

      Louro, Javier; Román, Marta; Moshina, Nataliia; Olstad, Camilla F.; Larsen, Marthe; Sagstad, Silje; Castells, Xavier; Hofvind, Solveig Sand-Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-12)
      Background: We aimed to develop and validate a model predicting breast cancer risk for women targeted by breast cancer screening. Method: This retrospective cohort study included 57,411 women screened at least once in BreastScreen Norway during the period from 2007 to 2019. The prediction model included information about age, mammographic density, family history of breast cancer, body mass index, ...
    • Possible strategies for use of artificial intelligence in screen-reading of mammograms, based on retrospective data from 122,969 screening examinations 

      Larsen, Marthe; Aglen, Camilla Flåt; Hoff, Solveig Roth; Lund-Hanssen, Håkon; Hofvind, Solveig Sand-Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-15)
      Objectives Artificial intelligence (AI) has shown promising results when used on retrospective data from mammographic screening. However, few studies have explored the possible consequences of different strategies for combining AI and radiologists in screen-reading.<p> <p>Methods A total of 122,969 digital screening examinations performed between 2009 and 2018 in BreastScreen Norway were retrospectively ...
    • Prolonged screening interval due to the COVID-19 pandemic and its association with tumor characteristics and treatment; a register-based study from BreastScreen Norway 

      Eijkelboom, Anouk H.; Larsen, Marthe; Siesling, Sabine; Nygård, Jan Franz; Hofvind, Solveig Sand-Hanssen; de Munck, Linda (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-11)
      Objective: During the COVID-19 pandemic Norway had to suspend its national breast cancer screening program. We aimed to investigate the effect of the pandemic-induced suspension on the screening interval, and its subsequent association with the tumor characteristics and treatment of screen-detected (SDC) and interval breast cancer (IC).<p> <p>Methods: Information about women aged 50–69, participating ...
    • Quality of life among women with symptomatic, screen-detected, and interval breast cancer, and for women without breast cancer: a retrospective cross-sectional study from Norway 

      Moshina, Nataliia; Falk, Ragnhild Sørum; Botteri, Edoardo; Larsen, Marthe; Akslen, Lars Andreas; Cairns, John Alexander; Hofvind, Solveig (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-26)
      Purpose - Breast cancers detected at screening need less aggressive treatment compared to breast cancers detected due to symptoms. The evidence on the quality of life associated with screen-detected versus symptomatic breast cancer is sparse. This study aimed to compare quality of life among Norwegian women with symptomatic, screen-detected and interval breast cancer, and women without breast cancer ...
    • Screen-detected and interval breast cancer after concordant and discordant interpretations in a population based screening program using independent double reading 

      Martiniussen, Marit Almenning; Sagstad, Silje; Larsen, Marthe; Larsen, Anne Sofie Frøyshov; Hovda, Tone; Lee, Christoph I.; Hofvind, Solveig Sand-Hanssen (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-02)
      Objectives - To analyze rates, odds ratios (OR), and characteristics of screen-detected and interval cancers after concordant and discordant initial interpretations and consensus in a population-based screening program.<p> <p>Methods - Data were extracted from the Cancer Registry of Norway for 487,118 women who participated in BreastScreen Norway, 2006–2017, with 2 years of follow-up. All mammograms ...